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it takes two to tango Mechanisms of altered transcriptional regulation moncler uk store through FOXOinteractions. Interaction of FOXO proteins with diverse transcription factor families or cofactors can lead to altered transcriptional responses through a variety of mechanisms. (a) Fusion proteins. chromosomal translocations in mixed lineage leukaemia or alveolar rhabdomyosarcoma result in the generation of FOXO fusion proteins. These are thought to have both more robust and altered transcriptional responses resulting in oncogenesis. (b) Transcriptional synergy. often FOXObinding elements are found adjoining or overlapping with other transcription factors. Association between these proteins can often result in enhanced transcriptional responses. (c) Recruitment of conventional cofactors. the recruitment of histone acetylase transferases (HATs) or histone deacetylases (HDACs) to promoters through association with transcription moncler uk factors can lead to activation or suppression of transcription. FOXOtranscription factor associations can result in altered cofactor distribution to target promoters. (d) Proteolytic degradation. association of FOXO proteins may lead to increased proteolytic degradation of FOXOs or associating transcription factors. (e) Transcription factor sequestration. transcription factors often form heterodimeric complexes when binding DNA. When one of these components is a limiting factor and also binds FOXOs, it may result in inhibition of transcription. (f) Displacement of regulatory moncler uk outlet cofactors. association of transcription factors with coactivators or corepressors modulates transcription. Displacement of these complexes by FOXO binding will result in altered transcriptional responses.